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Image Search Results
Journal: Oncogene
Article Title: Suppression of Tumorigenicity-14 , encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis
doi: 10.1038/onc.2011.545
Figure Lengend Snippet: Expression of ST14 , encoding matriptase, in 14 gene expression array studies of human colon adenomas and adenocarcinomas. Data are expressed as fold change relative to corresponding normal tissue. * P< 0.05, ** P <0.01, *** P <0.001. See for details and references.
Article Snippet: The sections were blocked for 1 h in 5% bovine serum albumin (Sigma-Aldrich), or 10% horse serum (for matriptase IHC) in PBS, and incubated overnight at 4 C with primary antibody:
Techniques: Expressing
Journal: Oncogene
Article Title: Suppression of Tumorigenicity-14 , encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis
doi: 10.1038/onc.2011.545
Figure Lengend Snippet: ( a , a ′) Immunohistochemical staining of eight week old St14 + ( a ) and littermate St14 − ( a ′) colons for β-catenin shows a membrane-associated β-catenin localization in St14 + epithelial cells ( arrows in a ), as compared to cytoplasmic and nuclear localization in adenocarcinomas of St14 − colons (examples with arrows in a ′). ( b , b ′) Immunohistochemical staining for the basement membrane marker laminin in 15 week old St14 + ( b ) and littermate St14 − ( b ′) mice shows the normal appearance of the basement membrane (example with arrow in b ) in St14 + mice. Loss of matriptase expression leads to increased deposition of laminin (examples with stars in b ′) and loss of normal structure of the basement membrane. ( c , c ′) Masson Trichrome staining of the colon of six week old St14 + ( c ) and littermate St14 − ( c ′) mice shows connective tissue in the submucosa of a normal colon (example with arrow in c ) and fibrosis of both the mucosa and submucosa of St14 − colon (examples with stars in c ′). ( d ) High magnification shows the cytological appearance of adenocarcinomas of St14 − mice. Atypical mitosis is shown by arrows . Scale bar = 200 μm ( a , a ′, b , b ′, c , c ′) and 20 μm ( d ).
Article Snippet: The sections were blocked for 1 h in 5% bovine serum albumin (Sigma-Aldrich), or 10% horse serum (for matriptase IHC) in PBS, and incubated overnight at 4 C with primary antibody:
Techniques: Immunohistochemical staining, Staining, Membrane, Marker, Expressing
Journal: Oncogene
Article Title: Suppression of Tumorigenicity-14 , encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis
doi: 10.1038/onc.2011.545
Figure Lengend Snippet: ( a , a ′) BrdU staining of eight week old St14 + ( a ) and littermate St14 − ( a ′) mice shows proliferation restricted to the bottom of the crypts of normal colons (examples with arrows in a ). In St14 − colon, proliferating cells are found both in the bottom (examples with arrows in a ′) and distal parts of crypts (examples with arrowheads in a ′). (b,b ′ ) Periodic Acid-Schiff (PAS) staining of mucopolysaccharides produced by differentiated goblet cells in the colon of eleven week old St14 + ( b ) and littermate St14 − ( b ′) mice. Red staining shows mucin in the normal colon ( arrows in b ). Absence of red staining in ( b ′) indicates cessation of mucin production in matriptase-ablated colon. ( c , c ′, d , d ′) Immunohistochemical staining for T-cells ( c , c ′) and B-cells ( d , d ′) in, respectively, seven and 15 week old St14 + ( c , d ) and littermate St14 − ( c ′, d ′) colons. Baseline levels of T-and B-cells in the lamina propria of St14 + colon (examples with arrows in d and c ) and abundance of T- and B-cells in both mucosa and submucosa of St14 − colons (examples with stars in c ′, d ′). Scale bar = 100 μm.
Article Snippet: The sections were blocked for 1 h in 5% bovine serum albumin (Sigma-Aldrich), or 10% horse serum (for matriptase IHC) in PBS, and incubated overnight at 4 C with primary antibody:
Techniques: BrdU Staining, Staining, Produced, Immunohistochemical staining
Journal: Oncogene
Article Title: Suppression of Tumorigenicity-14 , encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis
doi: 10.1038/onc.2011.545
Figure Lengend Snippet: The lumen of the colon and small intestine of weaning age St14 + and littermate St14 − animals was injected with Sulfo-NHS-LC-Biotin in PBS ( a , b , d , e ) or PBS ( c , f ). After three min, the intestine was excised, sectioned, and stained for biotin ( green ). Nuclei were stained with 4,6-diamino-2-phenylindol ( blue ). Arrows in a , d , and e show biotin bound to the surface of the mucosa. Arrowheads in b and the inset in e show biotin labeling of the basolateral membrane of polarized epithelial cells. The diffusion of biotin into intercellular space was not observed in the normal colon or small intestine ( a , d , also compare insets in d and e ). Stars show biotin labeling of connective tissue of both matriptase-ablated colon ( b ) and small intestine ( e ). There was no signal for biotin in colon and small intestine ( c , f ) injected with PBS. Scale bar = 20 μm.
Article Snippet: The sections were blocked for 1 h in 5% bovine serum albumin (Sigma-Aldrich), or 10% horse serum (for matriptase IHC) in PBS, and incubated overnight at 4 C with primary antibody:
Techniques: Injection, Staining, Labeling, Membrane, Diffusion-based Assay
Journal: Oncogene
Article Title: Suppression of Tumorigenicity-14 , encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis
doi: 10.1038/onc.2011.545
Figure Lengend Snippet: Histological appearance of St14 + ( a – e ) and littermate St14 − ( a ′- e ′) colons at postnatal day 0 ( a , a ′), 5 ( b , b ′), 10 ( c , c ′), 15 ( d , d ′), and 20 ( e , e ′). No histological differences can be observed between normal and matriptase-ablated colon at days 0 and 5 (compare a and a ′, b and b ′). At day 10, St14 − colons show sporadic foci of detaching and apoptotic cells ( arrowheads in c ′). This phenotype is significantly stronger at days 15 and 20 with extensive anoikis ( arrowheads in d ′), apoptotic cells ( arrows in d ′, e ′), ulcerations ( arrowhead in e ′) and inflammatory cell infiltrates ( star in e ′). Scale bar = 100 μm.
Article Snippet: The sections were blocked for 1 h in 5% bovine serum albumin (Sigma-Aldrich), or 10% horse serum (for matriptase IHC) in PBS, and incubated overnight at 4 C with primary antibody:
Techniques:
Journal: Oncogene
Article Title: Suppression of Tumorigenicity-14 , encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis
doi: 10.1038/onc.2011.545
Figure Lengend Snippet: Loss of matriptase from intestinal epithelium compromises epithelial barrier function thereby causing exposure of the commensal microbiota to resident immune cells. This triggers a repair response that includes activation of local inflammatory circuits and colonic stem cell activation. This response is perpetual, rather than transient, due to the intrinsic inability of matriptase-ablated to form a functional barrier. Persistent hyperproliferation of colonic stem cells within a DNA damaging chronic inflammatory microenvironment causes the formation of adenocarcinoma.
Article Snippet: The sections were blocked for 1 h in 5% bovine serum albumin (Sigma-Aldrich), or 10% horse serum (for matriptase IHC) in PBS, and incubated overnight at 4 C with primary antibody:
Techniques: Activation Assay, Functional Assay